Biopharmaceutics classification system (BCS) class IV compounds, exhibits least oral bioavailability, low solubility and intestinal permeability among all pharmaceutical classes of drugs. Thus, these drugs need more compatible and efficient delivery system. Since, their solubility in various medium, remains a limitation so, polymeric nano coacervates based drug loading with modified approach for them may prove to be a solution ahead. Therefore, in present study Chitosan is opted for encapsulating the BCS class IV drug (Hydrochlorothiazide) to attain better stability, enhanced permeability and lower toxicity. For this study, Hydrochlorothiazide (HCTZ) was opted for formulating chitosan based nano-coacervate system. Bcs Classification ListThe Biopharmaceutics Classification System (BCS) is a scientific framework for classifying drug substances based on their aqueous solubility and intestinal permeability. Ebarū Yashiki!!' エバルー屋敷!!) October 26, 2009 ( 2009-10-26) October 17, 2011 4 'Dear Kaby' ' Shin'ai Naru Kābii e' (DEAR KABY 〜親愛なるカービィへ〜) November 2, 2009 ( 2009-11-02) October 21, 2011 5 'The Wizard in Armor' ' Yoroi no Madōshi' (鎧の魔導士) November 9, 2009 ( 2009-11-09) — 6 'Fairies in the Wind' ' Yōsei-tachi wa Kaze no Naka' (妖精たちは風の中) November 16, 2009 ( 2009-11-16) — 7 'Flame and Wind' ' Honō to Kaze' (炎と風) November 23, 2009 ( 2009-11-23) — 8 'The Strongest Team' ' Saikyō Chīmu!!!' Erza' ' Natsu vs. (最強チーム!!!) November 30, 2009 ( 2009-11-30) — 9 'Natsu Devours a Village' ' Natsu, Mura o Kū' (ナツ、村を食う) December 7, 2009 ( 2009-12-07) — 10 'Natsu vs. Eruza' (ナツ vs. Watch fairy tail english dub. Optimized HCTZ nanocoacervates exhibited the average particle size of 91.39 ± 0.75 nm with Poly-dispersity index score of 0.159 ± 0.01, indicating homogeneity of colloidal solution. Zeta potential and encapsulation efficiency of HCTZ nanocoacervates were recorded as -18.9 ± 0.8 mV and 76.69 ± 0.82% respectively. Further, from TEM and SEM evaluation the average particle size for the same were found in conformity (35-50 nm), with almost spherical morphology. Also, the EDX (Electron Dispersive X-ray) spectrometry and FT - IR analysis of optimized formulation indicated the balanced chemical composition and interaction between the polymeric molecules. The HCTZ nano coacervates showed the linear diffusion profile through the dialysis membrane. We can conclude from the present study that the optimized HCTZ nano coacervates may prove to be a suitable potential option for effective delivery of BCS class IV drugs. Download full-text PDF Source DOI Listing PMC. ![]() • What are PubFacts Points? PubFacts points are rewards to PubFacts members, which allow you to better promote your profile and articles throughout PubFacts.com • How do I earn PubFacts Points? Each member is given 50 PubFacts points upon signing up. You can earn additional points by completing 100% of your profile, creating and participating in discussions, and sharing other members research. • What can I do with PubFacts Points? Currently, you can use PubFacts Points to promote and increase readership of your articles. • • 1.1k Downloads • Abstract The Biopharmaceutics Classification system (BCS) classifies drug substances based on aqueous solubility and intestinal permeability. The objective of this study was to use the World Health Organization Model List of Essential Medicines to determine the distribution of BCS Class 1, 2, 3, and 4 drugs in Abbreviated New drug Applications (ANDA) submissions. Download ms project 2013 full. Microsoft Project was the company's third Microsoft Windows-based application, and inside one or two of years of its introduction it became the dominant PC-based project management software package. May be a project management software package or a program, developed and sold-out by the corporate Microsoft, that is intended to help a project manager in developing an idea, assignment resources to tasks, trailing progress, managing the budget, and analyzing workloads. Bcs Class 1 DrugsTo categorize solubility and intestinal permeability properties of generic drugs under development, we used a list of 61 drugs which were classified as BCS 1, 2, 3, and 4 drugs with certainty in the World Health Organization Model List of Essential Medicines. Applying this list to evaluation of 263 ANDA approvals of BCS drugs during the period of 2000 to 2011 indicated 110 approvals (41.8%) for Class 1 drugs (based on both biowaiver and in vivo bioequivalence studies), 55 (20.9%) approvals for Class 2 drugs, 98 (37.3%) approvals for Class 3 drugs, and no (0%) approvals for Class 4 drugs. The present data indicated a trend of more ANDA approvals of BCS Class 1 drugs than Class 3 or Class 2 drugs. Antiallergic drugs in Class 1, drugs for pain relief in Class 2 and antidiabetic drugs in Class 3 have received the largest number of approvals during this period.
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